Lane 1: SiHa cell lysate
Lane 2: human lung tissue lysate
Rabbit polyclonal primary
GBP2 Rabbit Polyclonal Antibody (ER2001-12)
Synthetic peptide within human gbp2 aa 430-470.
SiHa cell lysate, human lung tissue lysate, human liver tissue, human liver carcinoma tissue, human colon tissue, human kidney tissue, A549.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Predicted band size: 67 kDa.
GBP 2 antibody; GTP binding protein 2 antibody; Guanine nucleotide binding protein 2 antibody; Guanylate binding protein 2 interferon inducible antibody; HuGBP 2 antibody; HuGBP2 antibody; Interferon induced guanylate binding protein 2 antibody
Golgi apparatus membrane, Cytoplasm, perinuclear region, Membrane.
Interferon-induced guanylate-binding protein 2 is a protein that in humans is encoded by the GBP2 gene. GBP2 is a gene related to the superfamily of large GTPases which can be induced mainly by interferon gamma. Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP. In addition, GBP2 gene can be a relationship between cell surface receptor and intracellular effectors which can transmit extracellular information into the cells as well as an intracellular signal transduction protein. A study on the bovine GBP2 gene showed the importance of GBP2 in the regulation of cell proliferation and the resistance to the pathogen infection such as an Exhibition of antiviral activity against influenza virus. GPB2 Promote an oxidative killing and deliver antimicrobial peptides to autophagolysosomal, providing broad host protection against different pathogen classes. During a viral infection, GBPs Family(GBP1, GBP2 and GBP5) play a vital role to activate canonical and non-canonical inflammasome to response to a pathogen infection via chlamydia muridarum.