GATA4 Mouse Monoclonal Antibody [7-4] (M1306-2)

UNIPROT #

Q08369

PROTEIN NAME

GATA4

SYNONYMS

ASD2 antibody;GATA 4 antibody;GATA binding protein 4 antibody;GATA-binding factor 4 antibody;gata4 antibody;GATA4_HUMAN antibody;MGC126629 antibody;Transcription factor GATA 4 antibody;Transcription factor GATA-4 antibody;Transcription factor GATA4 antibody;VSD1 antibody

POST-TRANSLATIONAL MODIFICATION

Methylation at Lys-300 attenuates transcriptional activity.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase.