GATA2 + GATA3 Recombinant Rabbit Monoclonal Antibody [JE04-46] (HA722713)

UNIPROT #

P23769

PROTEIN NAME

GATA2 + GATA3

SYNONYMS

DCML antibody;Endothelial transcription factor GATA 2 antibody;Endothelial transcription factor GATA-2 antibody;GATA binding factor 3 antibody;GATA binding protein 2 antibody;GATA binding protein 3 antibody;GATA-binding protein 2 antibody;GATA-binding protein 3 antibody;HDR antibody;HDRS antibody;IMD21 antibody;MONOMAC antibody;NFE1B antibody;Trans acting T cell specific transcription factor GATA 3 antibody;Trans acting T cell specific transcription factor GATA-3 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It regulates many genes that are critical for the embryonic development, self-renewal, maintenance, and functionality of blood-forming, lympathic system-forming, and other tissue-forming stem cells. GATA2 is encoded by the GATA2 gene, a gene which often suffers germline and somatic mutations which lead to a wide range of familial and sporadic diseases, respectively. The gene and its product are targets for the treatment of these diseases. GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.