Recombinant Rabbit monoclonal primary
GAP43 Recombinant Rabbit Monoclonal Antibody [SC60-06] (ET1610-94)
Synthetic peptide within human gap43 aa 189-238 / 238.
Mouse brain lysates, Hela, SHG-44, mouse brain tissue, SH-SY5Y.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Axonal membrane protein GAP 43 antibody; Axonal membrane protein GAP-43 antibody; B 50 antibody; Calmodulin binding protein P 57 antibody; F1 antibody; GAP 43 antibody; GAP43 antibody; Growth Associated Protein 43 antibody; Growth-associated protein 43 antibody; Nerve Growth Related Peptide antibody; Nerve growth related peptide GAP43 antibody; NEUM_HUMAN antibody; Neural phosphoprotein B 50 antibody; Neural phosphoprotein B-50 antibody; Neuromodulin antibody; Neuron growth associated protein 43 antibody; PP46 antibody; Protein F1 antibody; QtrA-11580 antibody; QtrA-13071 antibody
Belongs to the neuromodulin family.
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).; Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.
Cell membrane, Cell projection, Cell junction.
GAP-43 (growth associated protein 43, B-50, PP46, calmodulin-binding protein P-57, neuromodulin, neuron growth-associated protein 43, protein F1 is a crucial component for regenerative response in the nervous system. It is present at high levels in neuronal growth cones during development and axonal regeneration. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The neuron-specific Elav/Hu family member, HuD, interacts with and stabilizes GAP-43 mRNA in developing neurons and leads to increased levels of GAP-43 protein. Heterozygous GAP-43 knockout mice with GAP-43 levels reduced by one-half dipslay significant memory impairments in cued conditioning or on tests of nociceptive or auditory perception.
NLRP3 inflammasome is in......
NLRP3 inflammasome is involved in nerve recovery after sciatic nerve injury