gamma Sarcoglycan Recombinant Rabbit Monoclonal Antibody [JA11-57] (ET1704-24)

UNIPROT #

Q13326

PROTEIN NAME

gamma Sarcoglycan

SYNONYMS

35 kDa dystrophin associated glycoprotein antibody;35 kDa dystrophin-associated glycoprotein antibody;35DAG antibody;35kD dystrophin associated glycoprotein antibody;35kDa dystrophin-associated glycoprotein antibody;A4 antibody;DAGA4 antibody;DMDA antibody;DMDA1 antibody;Gamma SG antibody;Gamma-sarcoglycan antibody;Gamma-SG antibody;LGMD2C antibody;MAM antibody;MGC130048 antibody;Sarcoglycan gamma antibody;SCARMD2 antibody;SCG3 antibody;SGCG antibody;SGCG_HUMAN antibody;TYPE antibody

SEQUENCE SIMILARITIES

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

TISSUE SPECIFICITY

Expressed in skeletal and heart muscle.

SUBCELLULAR LOCATION

Cell membrane. Cytoplasm.

FUNCTION

The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac and smooth muscle fibers. Four sarcoglycan subunit proteins, designated α-, β-, γ- and δ-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, β- and δ-sarcoglycans are associated with ε-sarcoglycan, a glycoprotein homologous to α-sarcoglycan. Additionally, a complete deficiency in δ-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.