Lane 1: HepG2 cell lysate
Lane 2: A431 cell lysate
Rabbit polyclonal primary
GADD34 Rabbit Polyclonal Antibody (ER2001-56)
Synthetic peptide within human gadd34 aa 1-50.
HepG2 cell lysate, A431 cell lysate, human skin tissue, human prostate carcinoma tissue, human placenta tissue, K562.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Predicted band size: 73 kDa.
Apoptosis associated protein antibody; GADD 34 antibody; Growth arrest and DNA damage inducible 34 antibody; Growth arrest and DNA damage-inducible protein GADD34 antibody; Myeloid differentiation primary response protein MyD116 homolog antibody; Ppp1r15a antibody; PR15A_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody; Protein phosphatase 1 regulatory subunit 15A antibody
Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane.
Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a protein that in humans is encoded by the PPP1R15A gene. The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically suppress cell growth. Later on it has been characterized as a gene playing a role in ER stress-induced cell death, being a target of ATF4 that plays a role in ER-mediated cell death via promoting protein dephosphorylation of eIF2α and reversing translational inhibition. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.