GAD65 Recombinant Antibody [PSH06-80] - Rat IgG1 (Chimeric) (HA601389)

UNIPROT #

P48320

PROTEIN NAME

GAD65

SYNONYMS

65 kDa glutamic acid decarboxylase antibody;DCE 2 antibody;DCE2 antibody;DCE2_HUMAN antibody;GAD 2 antibody;GAD 65 antibody;GAD-2 antibody;GAD-65 antibody;Gad2 antibody;Glutamate decarboxylase 2 (pancreas) antibody;Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa) antibody;Glutamate decarboxylase 2 antibody;Glutamate Decarboxylase 65 antibody;Glutamate decarboxylase 65 kDa isoform antibody;Glutamic Acid Decarboxylase 2 antibody;Glutamic Acid Decarboxylase 65 antibody;MGC161605 antibody;MGC161607 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Cytoplasmic vesicle, Presynaptic cell membrane, Golgi apparatus membrane.

FUNCTION

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.