GABRB2 Rabbit Polyclonal Antibody (HA500289)
Catalog# HA500289
Rabbit Polyclonal to GABRB2
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WB
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IHC-P
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FC
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Human
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Mouse
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Rat
Positive control:
Lane 1: Human Brian tissue lysate
Lane 2: Rat cerebellum tissue lysate
Lane 3: Rat Brian tissue lysate
Predicted band size: 59 kDa
Observed band size: 80/50/65 kDa (Glycosylation)
Specifications
Product Type
Rabbit polyclonal primary
Product Name
GABRB2 Rabbit Polyclonal Antibody (HA500289)
Immunogen
Synthetic peptide within human gabrb2 aa 350-400 / 512 ((cytoplasmic).
Host
Rabbit
Positive Control
Human brian tissue lysate, rat cerebellum tissue lysate, rat brian tissue lysate, mouse brain tissue, A549.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:1,000
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IHC-P
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1:200
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FC
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1:500-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 59 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
GABRB2
SYNONYMS
GABA antibody;GABA(A) receptor beta 2 antibody;GABA(A) receptor subunit beta-2 antibody;GABA-A receptor, beta-2 polypeptide antibody;GABRB2 antibody;Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody;Gamma aminobutyric acid A receptor beta 2 antibody;Gamma-aminobutyric acid receptor subunit beta-2 antibody;Gamma-aminobutyric-acid receptor subunit beta-2 antibody;GBRB2_HUMAN antibody
SUBCELLULAR LOCATION
Cytoplasmic.
FUNCTION
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
CITATIONS
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Proteomic and metabolomic approaches elucidate the molecular mechanism of emodin against neuropathic pain through modulating the gamma‐aminobutyric acid (GABA)-ergic pathway and PI3K/AKT/NF-κB pathway
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WB
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Rat
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Citation
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