GABRA5 Rabbit Polyclonal Antibody (ER1902-82)

UNIPROT #

P31644

PROTEIN NAME

GABRA5

SYNONYMS

GAA 5 antibody;GAA5 antibody;GABA(A) receptor subunit alpha-5 antibody;GABRA 5 antibody;Gabra5 antibody;Gamma aminobutyric acid GABA A receptor alpha 5 antibody;Gamma aminobutyric acid GABA A receptor alpha 5 precursor antibody;Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor antibody;Gamma-aminobutyric acid receptor subunit alpha-5 antibody;GBRA5_HUMAN antibody;GC138184 antibody

SEQUENCE SIMILARITIES

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.

SUBCELLULAR LOCATION

Postsynaptic cell membrane, cell membrane.

FUNCTION

Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Recent research has produced several ligands which are moderately selective for GABAA receptors containing the α5 subunit. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.