GABRA1 Rabbit Polyclonal Antibody (ER1901-59)
Catalog# ER1901-59
Rabbit Polyclonal to GABRA1
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WB
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IF-Cell
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IHC-P
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FC
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Human
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
GABRA1 Rabbit Polyclonal Antibody (ER1901-59)
Immunogen
Synthetic peptide within rat gabra1 aa 11-60 / 455.
Host
Rabbit
Positive Control
Rat cerebellum tissue lysates, LOVO, rat brain tissue, Rat cerebellum tissue, SH-SY5Y.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB:1:500-1:2,000
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IF-Cell:1:50-1:100
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IHC-P:1:50-1:200
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FC:1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
52 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
GABRA1
SYNONYMS
ECA4 antibody;EIEE19 antibody;EJM antibody;EJM5 antibody;Gaba receptor alpha 1 polypeptide antibody;GABA(A) receptor antibody;GABA(A) receptor subunit alpha 1 antibody;GABA(A) receptor subunit alpha-1 antibody;GABA(A) receptor, alpha 1 antibody;GABRA 1 antibody;GABRA1 antibody;Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody;Gamma aminobutyric acid A receptor alpha 1 antibody;Gamma aminobutyric acid receptor subunit alpha 1 antibody;Gamma aminobutyric acid type A receptor alpha1 subunit antibody;Gamma-aminobutyric acid receptor subunit alpha-1 antibody;GBRA1_HUMAN antibody
SEQUENCE SIMILARITIES
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
POST-TRANSLATIONAL MODIFICATION
Glycosylated.
SUBCELLULAR LOCATION
Postsynaptic cell membrane, cell membrane, cytoplasmic vesicle membrane.
FUNCTION
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine.
CITATIONS
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JianhaoYang,et al
Exploring the mechanism of action of Huoermai Essential Oil for plateau insomnia based on the cAMP/CREB/BDNF/GABAergic pathway
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WB
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Mouse
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Citation
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