GABARAP Recombinant Rabbit Monoclonal Antibody [JM30-30] (ET1705-53)

UNIPROT #

O95166

PROTEIN NAME

GABARAP

SYNONYMS

ATG8A antibody;FLC 3B antibody;FLC3B antibody;FLJ25768 antibody;GABA type A receptor associated protein antibody;GABA(A) receptor associated protein antibody;GABA(A) receptor-associated protein antibody;GABARAP a antibody;GABARAP antibody;Gamma aminobutyric acid receptor associated protein antibody;Gamma-aminobutyric acid receptor-associated protein antibody;GBRAP_HUMAN antibody;MGC120154 antibody;MGC120155 antibody;MM 46 antibody;MM46 antibody

SEQUENCE SIMILARITIES

Belongs to the ATG8 family.

TISSUE SPECIFICITY

Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

POST-TRANSLATIONAL MODIFICATION

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.

SUBCELLULAR LOCATION

Endomembrane system. Cytoplasm, cytoskeleton.

FUNCTION

Gamma-aminobutyric acid receptor-associated protein is a protein that in humans is encoded by the GABARAP gene. Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Moreover, GABARAP has an important function in autophagosome mediated autophagy, since it is crucial for autophagosome formation and sequestration of cytosolic cargo into double-membrane vesicles, leading to subsequent degradation after fusion with lysosomes. In addition, GABARAP can mediate selective autophagy because it binds to so-called autophagic receptors (e.g. p62, NBr1), which bind and recruit specific cargo.