GABA B Receptor 2 Recombinant Rabbit Monoclonal Antibody [JU31-32] (ET7106-88)

UNIPROT #

O75899

PROTEIN NAME

GABA B Receptor 2

SYNONYMS

BcDNA:GH07312 antibody;CG6706 antibody;CT20836 antibody;D Gaba2 antibody;FLJ36928 antibody;G protein coupled receptor 51 antibody;G-protein coupled receptor 51 antibody;GAB B R2 antibody;GABA B R2 antibody;GABA B receptor 2 antibody;GABA-B receptor 2 antibody;GABA-B-R2 antibody;GABA-BR2 antibody;GABAB R2 antibody;GABABR 2 antibody;GABABR2 antibody;GABB R2 antibody;GABBR 2 antibody;Gabbr2 antibody;GABR2_HUMAN antibody;Gamma aminobutyric acid B receptor 2 antibody;Gamma aminobutyric acid GABA B receptor 2 antibody;Gamma aminobutyric acid type B receptor subunit 2 antibody;Gamma-aminobutyric acid type B receptor subunit 2 antibody;Gb 2 antibody;Gb2 antibody;GH07312 antibody;GPR 51 antibody;GPR51 antibody;GPRC 3B antibody;GPRC3B antibody;HG 20 antibody;HG20 antibody;HRIHFB2099 antibody;Metabotropic GABA B receptor subtype 2 antibody;OTTHUMP00000021776 antibody;OTTHUMP00000063797 antibody;R2 SUBUNIT antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

SUBCELLULAR LOCATION

Plasma membrane.

FUNCTION

In the central nervous system (CNS), gamma-aminobutyric acid (GABA) is the main main inhibitory neurotransmitter that functions to regulate neuronal firing. GABA exerts its effects through two different kinds of receptors: ionotropic receptors (GABAA R and GABAC R), which produce fast inhibitory signals, and metabotropic receptors (GABAB R), which produce slow inhibitory signals. The GABAB R receptor is a heterodimer that consists of two multi-pass membrane proteins, designated GABAB R1 and GABAB R2, both of which belong to the G protein-coupled receptor family and are highly expressed in brain tissue. Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning of inhibitory synaptic transmissions and are implicated in slow wave sleep, muscle relaxation, hippocampal long-term potentiation and antinociception events. Both GABAB R1 and GABAB R2 are regulated by G proteins that have a variety of functions, including activation of potassium channels, inhibition of adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipid hydrolysis.