GABA B Receptor 1 Recombinant Rabbit Monoclonal Antibody [PSH06-21] (HA722653)

UNIPROT #

Q9UBS5

PROTEIN NAME

GABA B Receptor 1

SYNONYMS

dJ271M21.1.1 antibody;dJ271M21.1.2 antibody;FLJ92613 antibody;GABA-B receptor 1 antibody;GABA-B-R1 antibody;GABA-BR1 antibody;GABAB R1 antibody;GABAB subunit 1c antibody;GABABR1 antibody;GABBR1 3 antibody;GABBR1 antibody;GABR1_HUMAN antibody;Gamma aminobutyric acid (GABA) B receptor 1 antibody;Gamma-aminobutyric acid type B receptor subunit 1 antibody;Gb1 antibody;GPRC3A antibody;Seven transmembrane helix receptor antibody

SUBCELLULAR LOCATION

Cell membrane, Postsynaptic cell membrane, Cell projection, dendrite; Secreted.

FUNCTION

Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene. GABAB1 is a receptor for Gamma-aminobutyric acid. Upon binding, GABAB1 will produce a slow and prolonged inhibitory effect. GABAB1 is one part of a heterodimer, which is the GABAB receptor, consisting of it and the related GABAB2 protein. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants. GABBR1 has been shown to interact with ATF4 and GABBR2.