GAB1 Recombinant Rabbit Monoclonal Antibody [JU47-19] (ET7106-70)

UNIPROT #

Q13480

PROTEIN NAME

GAB1

SYNONYMS

Gab 1 antibody;GAB1 antibody;GAB1_HUMAN antibody;GRB 2 associated binder 1 antibody;GRB 2 associated binding protein 1 antibody;GRB2 associated binding protein 1 isoform a antibody;GRB2 associated binding protein 1 isoform b antibody;GRB2-associated binder 1 antibody;GRB2-associated-binding protein 1 antibody;Growth factor receptor bound protein 2-associated protein 1 antibody

SEQUENCE SIMILARITIES

Belongs to the GAB family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway.