FZD2 Rabbit Polyclonal Antibody (HA500406)

UNIPROT #

Q14332

PROTEIN NAME

FZD2

SYNONYMS

Frizzled homolog 2 antibody;Frizzled-2 antibody;Frizzled2 antibody;Fz 2 antibody;Fz-2 antibody;Fz2 antibody;FZD 2 antibody;FZD2 antibody;FZD2_HUMAN antibody;FzE 2 antibody;FzE2 antibody;hFz 2 antibody;hFz2 antibody;Mfz10 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling. Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.