Applications
-
WB
-
IHC-P
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
FYCO1 Rabbit Polyclonal Antibody (ER2001-04)
Immunogen
Recombinant protein within human fyco1 aa 1-200.
Host
Rabbit
Positive Control
SK-Br-3 cell lysates, rat testis tissue, human liver tissue, human thyroid tissue, human colon tissue, mouse colon tissue, 293.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
167 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB:1:500
-
IHC-P:1:200-1:1,000
-
FC:1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
FYCO1
SYNONYMS
CATC2 antibody; CTRCT18 antibody; DKFZp779K1152 antibody; FLJ13335 antibody; FYCO1 antibody; FYCO1_HUMAN antibody; FYVE and coiled coil domain containing 1 antibody; FYVE and coiled coil domain containing protein 1 antibody; FYVE and coiled-coil domain-containing protein 1 antibody; MGC126517 antibody; MGC126519 antibody; RUFY3 antibody; RUN and FYVE domain containing 3 antibody; ZFYVE7 antibody; Zinc finger FYVE domain containing protein 7 antibody; Zinc finger FYVE domain-containing protein 7 antibody
SUBCELLULAR LOCATION
Lysosome, Endosome, autophagosome.
FUNCTION
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).