FUS/TLS Recombinant Rabbit Monoclonal Antibody [JJ09-31] (ET1701-86)

UNIPROT #

P35637

PROTEIN NAME

FUS/TLS

SYNONYMS

75 kDa DNA pairing protein antibody;75 kDa DNA-pairing protein antibody;ALS6 antibody;Amyotrophic lateral sclerosis 6 antibody;fus antibody;FUS CHOP antibody;Fus like protein antibody;FUS_HUMAN antibody;FUS1 antibody;Fused in sarcoma antibody;Fusion (involved in t(12;16) in malignant liposarcoma) antibody;Fusion derived from t(12;16) malignant liposarcoma antibody;Fusion gene in myxoid liposarcoma antibody;Heterogeneous nuclear ribonucleoprotein P2 antibody;hnRNP P2 antibody;hnRNPP2 antibody;Oncogene FUS antibody;Oncogene TLS antibody;POMp75 antibody;RNA binding protein FUS antibody;RNA-binding protein FUS antibody;TLS antibody;TLS CHOP antibody;Translocated in liposarcoma antibody;Translocated in liposarcoma protein antibody

SEQUENCE SIMILARITIES

Belongs to the RRM TET family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.; Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

EWS and FUS/TLS are nuclear RNA-binding proteins. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1, in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various Ets transcription factors, including Fli-1, ETV1 and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. In human myxoid liposarcomas and myeloid leukemias, chromosomal translocation results in the fusion of the N-terminal region of FUS/TLS with the open reading frame of CHOP. In normal cells, FUS/TLS binds to the DNA-binding domains of nuclear steroid receptors and is also present in subpopulations of TFIID complexes, indicating a potential role for FUS/TLS in the processing of primary transcripts that are generated in response to hormone-induced transcription.