Furin Recombinant Rabbit Monoclonal Antibody [JB35-53] (ET7107-37)

UNIPROT #

P09958

PROTEIN NAME

Furin

SYNONYMS

Dibasic processing enzyme antibody;Dibasic-processing enzyme antibody;FES upstream region antibody;FUR antibody;FURIN antibody;Furin membrane associated receptor protein antibody;FURIN_HUMAN antibody;PACE antibody;Paired basic amino acid residue cleaving enzyme antibody;Paired basic amino acid residue-cleaving enzyme antibody;PCSK3 antibody;Proprotein convertase subtilisin/kexin type 3 antibody;SPC1 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S8 family. Furin subfamily.

TISSUE SPECIFICITY

Seems to be expressed ubiquitously.

POST-TRANSLATIONAL MODIFICATION

The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.; Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.

SUBCELLULAR LOCATION

Secreted. Plasma membrane. Golgi apparatus. Endosome.

FUNCTION

Furin is a protease enzyme that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme). A member of family S8, furin is a subtilisin-like peptidase. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor.