FUBP1 Recombinant Rabbit Monoclonal Antibody [SY11-04] (ET1605-26)

UNIPROT #

Q96AE4

PROTEIN NAME

FUBP1

SYNONYMS

DNA helicase V antibody;far upstream element (FUSE) binding protein 1 antibody;Far upstream element (FUSE) binding protein 4 antibody;Far upstream element binding protein 1 antibody;far upstream element binding protein antibody;Far upstream element-binding protein 1 antibody;FBP antibody;FUBP antibody;Fubp1 antibody;FUBP1_HUMAN antibody;Fubp4 antibody;FUSE binding protein 1 antibody;FUSE-binding protein 1 antibody;HDH V antibody

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated. This targets the protein for proteasome-mediated degradation.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation.