Frizzled 8 Recombinant Rabbit Monoclonal Antibody [JB40-16] (ET7107-68)

UNIPROT #

Q9H461

PROTEIN NAME

Frizzled 8

SYNONYMS

Frizzled 8 seven transmembrane spanning receptor antibody;frizzled 8, seven transmembrane spanning receptor antibody;Frizzled family receptor 8 antibody;frizzled homolog 8 (Drosophila) antibody;Frizzled homolog 8 antibody;Frizzled-8 antibody;FZ 8 antibody;Fz-8 antibody;FZ8 antibody;FZD 8 antibody;FZD8 antibody;FZD8_HUMAN antibody;hFZ 8 antibody;hFz8 antibody;HGNC4046 antibody;Homolog of Drosophila Frizzled 8 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor Fz/Smo family.

TISSUE SPECIFICITY

Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

SUBCELLULAR LOCATION

Golgi apparatus. Membrane.

FUNCTION

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.