Rabbit polyclonal primary
Frizzled-5 Rabbit Polyclonal Antibody (0905-3)
Synthetic peptide within human frizzled-5 of aa 168-181.
Human ES cell, A549, LOVO, HepG2.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
C2orf31 antibody; DKFZP434E2135 antibody; Frizzled 5 seven transmembrane spanning receptor antibody; Frizzled class receptor 5 antibody; Frizzled family receptor 5 antibody; Frizzled homolog 5 antibody; Frizzled-5 antibody; Frizzled5 antibody; Fz 5 antibody; Fz-5 antibody; Fz5 antibody; FZD 5 antibody; fzd5 antibody; FZD5_HUMAN antibody; FzE 5 antibody; FzE5 antibody; HFZ 5 antibody; hFz5 antibody; MGC129692 antibody; Seven transmembrane receptor frizzled 5 antibody; Uncharacterized protein C2orf31 antibody; Wnt receptor antibody
Belongs to the G-protein coupled receptor Fz/Smo family.
Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.
Cell membrane.Golgi apparatus. Membrane. Synapse.
Frizzled-5 belongs to the G-protein coupled receptor Fz/Smo family, contains 585 amino acids. It is localized at the plasma membrane and also found at the Golgi. Fzds have a large extracellular N-terminal region containing a cysteine-rich domain (CRD), which is involved in binding to Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.