Positive control:
Lane 1: Hela
Lane 2: Jurkat
Lane 3: MCF-7
Applications
-
WB
-
IHC-P
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Recombinant Rabbit monoclonal primary
Product Name
FOXP1 Recombinant Rabbit Monoclonal Antibody [JF1017] (ET1702-44)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
Jurkat, MCF-7, Hela, human colon cancer tissue, human breast carcinoma tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JF1017
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A purified.
MOLECULAR WEIGHT
77/75 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:1,000-1:5,000
-
FC
-
1:50-1:100
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
FOXP1
SYNONYMS
12CC4 antibody; FLJ23741 antibody; Fork head related protein like B antibody; Forkhead box P1 antibody; Forkhead box protein P1 antibody; FOX P1 antibody; FOXP 1 antibody; foxp1 antibody; FOXP1_HUMAN antibody; Glutamine rich factor 1 antibody; hFKH1B antibody; HSPC215 antibody; MGC12942 antibody; MGC88572 antibody; MGC99551 antibody; QRF 1 antibody; QRF1 antibody
TISSUE SPECIFICITY
Isoform 8 is specifically expressed in embryonic stem cells.
SUBCELLULAR LOCATION
Nucleus.
FUNCTION
The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1. The gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23-Xq13.3. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T-cell activation.