FOXO4 Recombinant Rabbit Monoclonal Antibody [JJ09-11] (ET1701-67)

UNIPROT #

P98177

PROTEIN NAME

FOXO4

SYNONYMS

AFX antibody;AFX1 antibody;Afxh antibody;ALL1-fused gene from X chromosome antibody;Fork head domain transcription factor AFX1 antibody;Forkhead box O4 antibody;Forkhead box protein O4 antibody;FOXO 4 antibody;Foxo4 antibody;FOXO4_HUMAN antibody;MGC117660 antibody;MGC120490 antibody;Mixed lineage leukemia, translocated to, 7 antibody;MLLT7 antibody;Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 antibody;Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody;RGD1561201 antibody

TISSUE SPECIFICITY

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

POST-TRANSLATIONAL MODIFICATION

Acetylation by CREBBP/CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.; Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK.; Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7; deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently, deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.