Applications
-
WB
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
FOXF2 Rabbit Polyclonal Antibody (ER1802-3)
Immunogen
Synthetic peptide within human foxf2 aa 373-422 / 444.
Host
Rabbit
Positive Control
Human placenta tissue, human lung cancer tissue, mouse lung tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified
MOLECULAR WEIGHT
46 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500
TARGET
UNIPROT #
PROTEIN NAME
FOXF2
SYNONYMS
FKH L6 antibody; FKHL 6 antibody; FKHL6 antibody; Forkhead box F2 antibody; Forkhead box protein F2 antibody; Forkhead like 6 antibody; Forkhead related activator 2 antibody; Forkhead related protein FKHL6 antibody; Forkhead related transcription factor 2 antibody; Forkhead, Drosophila, homolog-like 6 antibody; FOX F2 antibody; FOXF 2 antibody; FREAC 2 antibody; FREAC2 antibody; OTTHUMP00000017863 antibody
TISSUE SPECIFICITY
Lung and placenta. Predominantly expressed in gastrointestinal tract including stomach.
SUBCELLULAR LOCATION
Nucleus.
FUNCTION
The FOX family of transcription factors share a common DIUA binding domain termed a winged-helix or forkhead domain. Many FOX proteins play important roles in development, metabolism, cancer and aging. Development of the vertebrate gut is controlled by paracrine crosstalk between the endodermal epithelium and the associated splanchnic mesoderm. FOXF2 (forkhead box F2), also known as FKHL or FREAC2, is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. FOXF2 interacts with transcription factors TFIIB and TBP, and may be involved in regulating transcription in embryogenesis and pattern formation in multicellular organisms. FOXF2-deficient mice develop cleft palate and an abnormal tongue, which suggests that FOXF2 may be critical for palatogenesis.