FOXD3 Rabbit Polyclonal Antibody (R1107-4)

UNIPROT #

Q9UJU5

PROTEIN NAME

FOXD3

SYNONYMS

AIS1 antibody;forkhead box D3 antibody;Forkhead box protein D3 antibody;foxd3 antibody;FOXD3_HUMAN antibody;Genesis antibody;HFH2 antibody;HNF3/FH transcription factor genesis antibody;VAMAS2 antibody

TISSUE SPECIFICITY

Expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord.

DEVELOPMENTAL STAGE

During early embryogenesis, not expressed in unfertilized oocytes or fertilized one-cell embryos but detected in blastocysts.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Forkhead box protein D3 (FOXD3) acts as a transcriptional repressor and binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord. A variety of growth factors induce FoxD3 expression, including FGF8 and SNAIL, maintaining the effected cells in an undifferentiated state.