FOXA2 Recombinant Rabbit Monoclonal Antibody [JM10-64] (ET1703-76)

UNIPROT #

Q9Y261

PROTEIN NAME

FOXA2

SYNONYMS

Forkhead box A2 antibody;Forkhead box protein A2 antibody;FOX A2 antibody;foxa2 antibody;FOXA2_HUMAN antibody;Hepatic nuclear factor 3 beta antibody;Hepatocyte nuclear factor 3 antibody;Hepatocyte nuclear factor 3 beta antibody;Hepatocyte nuclear factor 3-beta antibody;HNF 3B antibody;HNF-3-beta antibody;HNF-3B antibody;HNF3B antibody;MGC19807 antibody;TCF 3B antibody;TCF-3B antibody;TCF3B antibody;Transcription factor 3B antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.