FMO3 Recombinant Rabbit Monoclonal Antibody [JE55-13] (HA721971)

UNIPROT #

P31513

PROTEIN NAME

FMO3

SYNONYMS

Dimethylaniline monooxygenase [N oxide forming] 3 antibody;Dimethylaniline monooxygenase [N-oxide-forming] 3 antibody;Dimethylaniline monooxygenase 3 antibody;Dimethylaniline oxidase 3 antibody;dJ127D3.1 antibody;Flavin containing monooxygenase 3 antibody;FMO 3 antibody;FMO form 2 antibody;FMO II antibody;FMO3 antibody;FMO3_HUMAN antibody;FMOII antibody;Hepatic flavin containing monooxygenase 3 antibody;Hepatic flavin-containing monooxygenase 3 antibody;MGC34400 antibody;TMAU antibody;Trimethylamine monooxygenase antibody

SUBCELLULAR LOCATION

Microsome membrane, Endoplasmic reticulum membrane.

FUNCTION

Flavin-containing monooxygenase 3 (FMO3), also known as dimethylaniline monooxygenase [N-oxide-forming] 3 and trimethylamine monooxygenase, is a flavoprotein enzyme (EC 1.14.13.148) that in humans is encoded by the FMO3 gene. FMO3 is the primary enzyme in humans which catalyzes the N-oxidation of trimethylamine into trimethylamine N-oxide; FMO1 also does this, but to a much lesser extent than FMO3. Genetic deficiencies of the FMO3 enzyme cause primary trimethylaminuria, also known as "fish odor syndrome". FMO3 is also involved in the metabolism of many xenobiotics (i.e., exogenous compounds which are not normally present in the body), such as the oxidative deamination of amphetamine.