FLAP Recombinant Rabbit Monoclonal Antibody [JE39-03] (HA722341)

UNIPROT #

P20292

PROTEIN NAME

FLAP

SYNONYMS

5-lipoxygenase activating protein antibody;AL5AP_HUMAN antibody;ALOX 5AP antibody;ALOX5 AP antibody;ALOX5AP antibody;Arachidonate 5 lipoxygenase activating protein antibody;Arachidonate 5-lipoxygenase-activating protein antibody;Five lipoxygenase activating protein antibody;FLAP antibody;MK 886 binding protein antibody;MK-886-binding protein antibody

SUBCELLULAR LOCATION

Nucleus membrane, Endoplasmic reticulum membrane.

FUNCTION

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene. FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consists of 4 transmembrane alpha helices, but they are found in trimer forming a barrel. The barrel is about 60 Å high and 36 Å wide.