Lane 1: Daudi cell lysate
Lane 2: Hela cell lysate
Recombinant Rabbit monoclonal primary
FKBP51 Recombinant Rabbit Monoclonal Antibody [JB95-39] (ET7107-64)
Daudi cell lysate, Hela cell lysate, human tonsil tissue, human kidney tissue, rat lung tissue, Daudi.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
51 kDa FK506 binding protein 5 antibody; 51 kDa FK506 binding protein antibody; 51 kDa FK506-binding protein antibody; 51 kDa FKBP antibody; 54 kDa progesterone receptor associated immunophilin antibody; 54 kDa progesterone receptor-associated immunophilin antibody; AIG 6 antibody; AIG6 antibody; Androgen regulated protein 6 antibody; Androgen-regulated protein 6 antibody; FF1 antigen antibody; FK506 binding protein 5 antibody; FK506-binding protein 5 antibody; FKBP 5 antibody; FKBP 51 antibody; FKBP 54 antibody; FKBP-5 antibody; FKBP-51 antibody; FKBP5 antibody; FKBP5_HUMAN antibody; FKBP54 antibody; HSP90 binding immunophilin antibody; HSP90-binding immunophilin antibody; MGC111006 antibody; OTTHUMP00000016268 antibody; P54 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP5 antibody; Peptidylprolyl cis trans isomerase antibody; PPIase antibody; PPIase FKBP5 antibody; Ptg 10 antibody; Ptg10 antibody; Rotamase antibody; T cell FK506 binding protein antibody
Widely expressed, enriched in testis compared to other tissues.
Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation.
The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin. The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGFβ-type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGFβ pathway. FKBP51 and FKBP52 are two highly related proteins. FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids. FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation. FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6,8).