Lane 1: SH-SY5Y cell lysate
Lane 2: U937 cell lysate
Recombinant Rabbit monoclonal primary
FKBP12 Recombinant Rabbit Monoclonal Antibody [JM11-09] (ET1703-55)
Synthetic peptide within human fkbp12 aa 76-108 / 108.
SH-SY5Y, V937, HepG2, A431, Hela.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
12 kDa FK506-binding protein antibody; 12 kDa FKBP antibody; Calstabin 1 antibody; FK506 binding protein 1 antibody; FK506 binding protein 12 antibody; FK506 binding protein 1A (12kD) antibody; FK506 binding protein 1A 12kDa antibody; FK506 binding protein 1A antibody; FK506 binding protein T cell 12 kD antibody; FK506 binding protein, T cell, 12 kD antibody; FK506 binding protein12 antibody; FK506-binding protein 1A antibody; FKB1A_HUMAN antibody; FKBP 12 antibody; FKBP 1A antibody; FKBP-12 antibody; FKBP-1A antibody; FKBP1 antibody; FKBP12 antibody; FKBP12 Exip3 antibody; FKBP12C antibody; fkbp1a antibody; Immunophilin FKBP12 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP1A antibody; PKC12 antibody; PKCI2 antibody; PPIase antibody; PPIase FKBP1A antibody; Protein kinase C inhibitor 2 antibody; Rotamase antibody
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBP-type PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing.