Fibrinogen gamma chain Recombinant Rabbit Monoclonal Antibody [JG37-18] (ET7108-46)

UNIPROT #

P02679

PROTEIN NAME

Fibrinogen gamma chain

SYNONYMS

FGG antibody;FIBG_HUMAN antibody;Fibrinogen gamma chain antibody;Fibrinogen gamma polypeptide antibody;fibrinogen gamma-b chain antibody

TISSUE SPECIFICITY

Detected in blood plasma (at protein level).

POST-TRANSLATIONAL MODIFICATION

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.; Sulfation of C-terminal tyrosines increases affinity for thrombin.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.