FHIT Recombinant Rabbit Monoclonal Antibody [JE33-58] (HA722390)

UNIPROT #

P49789

PROTEIN NAME

FHIT

SYNONYMS

AP3A hydrolase antibody;AP3A hydrolase fragile site 3p14.2 antibody;AP3Aase antibody;Bis 5' adenosyl triphosphatase antibody;Bis(5' adenosyl) triphosphatase antibody;Diadenosine 5' 5''' P1 P3 triphosphate hydrolase antibody;Dinucleosidetriphosphatase antibody;FRA 3B antibody;FRA3B antibody;Fragile histidine triad antibody;Fragile histidine triad gene antibody;Fragile histidine triad protein antibody;Tumor suppressor protein antibody;FHIT

SUBCELLULAR LOCATION

Cytoplasm, Mitochondrion, Nucleus.

FUNCTION

Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. FHIT is also known as human accelerated region 10. It may, therefore, have played a key role in differentiating humans from apes. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies. Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. FHIT also acts as a tumor suppressor of HER2/neu driven breast cancer.