Ferritin Heavy Chain Recombinant Rabbit Monoclonal Antibody [JM22-36] (ET1705-55)

UNIPROT #

P02794

PROTEIN NAME

Ferritin Heavy Chain

SYNONYMS

Apoferritin antibody;Cell proliferation inducing gene 15 protein antibody;Cell proliferation-inducing gene 15 protein antibody;F HC antibody;Ferritin H subunit antibody;Ferritin heavy chain antibody;Ferritin heavy polypeptide 1 antibody;FHC antibody;FRIH antibody;FRIH_HUMAN antibody;FTH 1 antibody;FTH antibody;FTH1 antibody;FTH1 protein antibody;FTHL 6 antibody;FTHL6 antibody;Iron overload autosomal dominant antibody;MGC104426 antibody;N-terminally processed antibody;OK/SW-cl.84 antibody;PIG 15 antibody;PIG15 antibody;Placenta immunoregulatory factor antibody;PLIF antibody;Proliferation inducing gene 15 protein antibody;Proliferation inducing protein 15 antibody

SEQUENCE SIMILARITIES

Belongs to the ferritin family.

TISSUE SPECIFICITY

Expressed in the liver.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Mammalian ferritins consist of 24 subunits made up of two types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of FeII, whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of FeIII. The most prominent role of mamma-lian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.