Ferritin Rabbit Polyclonal Antibody (R1601-9)

UNIPROT #

P02794

PROTEIN NAME

Ferritin

SYNONYMS

Cell proliferation-inducing gene 15 protein antibody;Ferritin H subunit antibody;Ferritin heavy chain antibody;Ferritin heavy polypeptide 1 antibody;Ferritin L subunit antibody;Ferritin light polypeptide antibody;Ferritin, heavy polypeptide antibody;FRIH_HUMAN antibody;FTH antibody;FTH1 antibody;FTL antibody

SEQUENCE SIMILARITIES

Belongs to the ferritin family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Mammalian ferritins consist of 24 subunits made up of two types of polypeptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts. The gene encoding human ferritin heavy chain maps to chromosome 11q13 and the human ferritin light chain gene maps to chromosome 19q13.3-q13.4.