FCGRT Rabbit Polyclonal Antibody (HA500006)

UNIPROT #

P55899

PROTEIN NAME

FCGRT

SYNONYMS

Alpha chain antibody;Fc fragment of IgG, receptor transporter, alpha antibody;FCGRN_HUMAN antibody;FCGRT antibody;FcRn alpha chain antibody

SUBCELLULAR LOCATION

Cell membrane, Endosome, Membrane.

FUNCTION

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.