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FBXW7 Rabbit Polyclonal Antibody (ER1706-78)

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Catalog# ER1706-78

Rabbit Polyclonal to FBXW7

Tested for

  • WB

  • ICC

  • FC

  • IHC-P

React with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

FBXW7 Rabbit Polyclonal Antibody (ER1706-78)

Immunogen

Recombinant protein within human fbxw7 aa 84-327.

Host

Rabbit

Positive Control

Mouse spleen tissue lysate, rat lung tissue lysate, HepG2 cell lysate, HUVEC, SH-SY5Y.

Conjugation

Unconjugated

Clonality

Polyclonal

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • ICC

  • 1:500-1:2,000

  • FC

  • 1:50-1:100

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

70 kDa

Isotype

IgG

TARGET

UNIPROT #

Q969H0

PROTEIN NAME

FBXW7

SYNONYMS

AGO antibody;Archipelago antibody;Archipelago homolog antibody;Archipelago, Drosophila, homolog of antibody;CDC4 antibody;CDC4, S.cerevisiae, homolog of antibody;DKFZp686F23254 antibody;F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody;F box and WD 40 domain protein 7 antibody;F box and WD repeat domain containing 7 antibody;F box protein FBW7 antibody;F box protein FBX30 antibody;F box protein SEL 10 antibody;F box protein SEL10 antibody;F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody;F-box and WD-40 domain-containing protein 7 antibody;F-box protein FBX30 antibody;F-box/WD repeat-containing protein 7 antibody;FBW6 antibody;FBW7 antibody;FBX30 antibody;FBXO30 antibody;FBXW6 antibody;FBXW7 antibody;FBXW7_HUMAN antibody;FLJ16457 antibody;hAgo antibody;hCdc4 antibody;Homolog of C elegans sel 10 antibody;Homolog of C.elegans sel10 antibody;SEL 10 antibody;SEL-10 antibody;SEL10 antibody

TISSUE SPECIFICITY

Isoform 1 is widely expressed. Isoform 3 is expressed in brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Thr-205 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation.; Ubiquitinated: autoubiquitinates following phosphorylation at Thr-205 and subsequent interaction with PIN1. Ubiquitination leads to its proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation

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