FBXL2 Rabbit Polyclonal Antibody (R1706-15)

UNIPROT #

Q9UKC9

PROTEIN NAME

FBXL2

SYNONYMS

DKFZP564P0622 antibody;F box and leucine rich repeat protein 2 antibody;F box protein containing leucine rich repeats antibody;F box protein FBL2/FBL3 antibody;F box/LRR repeat protein 2 antibody;F-box and leucine-rich repeat protein 2 antibody;F-box protein FBL2/FBL3 antibody;F-box/LRR-repeat protein 2 antibody;FBL 2 antibody;FBL 3 antibody;FBL2 antibody;FBL3 antibody;FBXL 2 antibody;FBXL2 antibody;FBXL2_HUMAN antibody

TISSUE SPECIFICITY

Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.