PRODUCT CODE: 0810-1

FADD Rabbit Polyclonal Antibody (0810-1)

Applications

  • WB

  • FC

REACTIVITY

  • Mouse

Western blot analysis on mouse heart lysates using anti-FADD polyclonal antibody
  • Western blot analysis on mouse heart lysates using anti-FADD polyclonal antibody
Western blot analysis on mouse heart lysates using anti-FADD polyclonal antibody

Applications

  • WB

  • FC

REACTIVITY

  • Mouse

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

FADD Rabbit Polyclonal Antibody (0810-1)

Immunogen

Synthetic peptide within mouse fadd aa 1-50 / 205.

Host

Rabbit

Positive Control

Mouse heart

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

27 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:2,000

TARGET

UNIPROT #

PROTEIN NAME

FADD

SYNONYMS

FADD antibody; FADD protein antibody; FADD_HUMAN antibody; Fas (TNFRSF6) associated via death domain antibody; Fas associated via death domain antibody; Fas associating death domain containing protein antibody; Fas associating protein antibody; Fas associating protein with death domain antibody; Fas TNFRSF6 associated via death domain antibody; FAS-associated death domain protein antibody; FAS-associating death domain-containing protein antibody; GIG 3 antibody; GIG3 antibody; Growth inhibiting gene 3 protein antibody; Growth-inhibiting gene 3 protein antibody; H sapiens mRNA for mediator of receptor induced toxicity antibody; Mediator of receptor induced toxicity antibody; MGC8528 antibody; MORT 1 antibody; MORT1 antibody; Protein FADD antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated.

SUBCELLULAR LOCATION

Cell cytosol

FUNCTION

The Fas-associated death domain-containing protein (FADD) was initially identified as an adaptor required for cell death signal transduction initiated by Fas. FADD contains two protein-protein interaction structures: the death domain (DD) at the carboxy terminus and the death effector domain (DED) at the amino terminus. FADD is involved in signaling induced by other DRs such as TNFR-I, TRAIL receptors (or DR4/5), and DR3. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases.