UNIPROT #

Q61160

PROTEIN NAME

FADD

SYNONYMS

FADD antibody; FADD protein antibody; FADD_HUMAN antibody; Fas (TNFRSF6) associated via death domain antibody; Fas associated via death domain antibody; Fas associating death domain containing protein antibody; Fas associating protein antibody; Fas associating protein with death domain antibody; Fas TNFRSF6 associated via death domain antibody; FAS-associated death domain protein antibody; FAS-associating death domain-containing protein antibody; GIG 3 antibody; GIG3 antibody; Growth inhibiting gene 3 protein antibody; Growth-inhibiting gene 3 protein antibody; H sapiens mRNA for mediator of receptor induced toxicity antibody; Mediator of receptor induced toxicity antibody; MGC8528 antibody; MORT 1 antibody; MORT1 antibody; Protein FADD antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated.

SUBCELLULAR LOCATION

Cell cytosol

FUNCTION

The Fas-associated death domain-containing protein (FADD) was initially identified as an adaptor required for cell death signal transduction initiated by Fas. FADD contains two protein-protein interaction structures: the death domain (DD) at the carboxy terminus and the death effector domain (DED) at the amino terminus. FADD is involved in signaling induced by other DRs such as TNFR-I, TRAIL receptors (or DR4/5), and DR3. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases.