FADD Rabbit Polyclonal Antibody (0810-1)

UNIPROT #

Q61160

PROTEIN NAME

FADD

SYNONYMS

FADD antibody;FADD protein antibody;FADD_HUMAN antibody;Fas (TNFRSF6) associated via death domain antibody;Fas associated via death domain antibody;Fas associating death domain containing protein antibody;Fas associating protein antibody;Fas associating protein with death domain antibody;Fas TNFRSF6 associated via death domain antibody;FAS-associated death domain protein antibody;FAS-associating death domain-containing protein antibody;GIG 3 antibody;GIG3 antibody;Growth inhibiting gene 3 protein antibody;Growth-inhibiting gene 3 protein antibody;H sapiens mRNA for mediator of receptor induced toxicity antibody;Mediator of receptor induced toxicity antibody;MGC8528 antibody;MORT 1 antibody;MORT1 antibody;Protein FADD antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated.

SUBCELLULAR LOCATION

Cell cytosol

FUNCTION

The Fas-associated death domain-containing protein (FADD) was initially identified as an adaptor required for cell death signal transduction initiated by Fas. FADD contains two protein-protein interaction structures: the death domain (DD) at the carboxy terminus and the death effector domain (DED) at the amino terminus. FADD is involved in signaling induced by other DRs such as TNFR-I, TRAIL receptors (or DR4/5), and DR3. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases.