FAB1A Rabbit Polyclonal Antibody (HA500403)

UNIPROT #

Q0WUR5

PROTEIN NAME

FAB1A

SYNONYMS

1-phosphatidylinositol-3-phosphate 5-kinase FAB1A;Phosphatidylinositol 3-phosphate 5-kinase;FYVE finger-containing phosphoinositide kinase;PIKfyve;Phosphatidylinositol 3-phosphate 5-kinase type III;PIPkin-III;Type III PIP kinase;Protein FORMS APLOID AND BINUCLEATE CELLS 1A;FAB1A;At4g33240;F4I10.170

SUBCELLULAR LOCATION

Endosome membrane.

FUNCTION

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters.