F4/80 Recombinant Antibody - Rat IgG1 (Chimeric) (IRS143RT)

UNIPROT #

Q61549

PROTEIN NAME

F4/80

SYNONYMS

ADGRE1 antibody;Adhesion G protein coupled receptor E1 antibody;Adhesion G protein-coupled receptor E1 antibody;AGRE1_HUMAN antibody;Cell surface glycoprotein EMR1 antibody;Cell surface glycoprotein F4/80 antibody;DD7A5 7 antibody;Egf like module containing mucin like hormone receptor like 1 antibody;Egf like module containing mucin like hormone receptor like sequence 1 antibody;EGF like module receptor 1 antibody;EGF TM7 antibody;EGF-like module receptor 1 antibody;EGF-like module-containing mucin-like hormone receptor-like 1 antibody;EGFTM7 antibody;EMR 1 antibody;EMR1 antibody;EMR1 hormone receptor antibody;Gpf480 antibody;Ly71 antibody;Lymphocyte antigen 71 antibody;TM7LN3 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene. EMR1 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations. The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse. Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.