Recombinant Rabbit monoclonal primary
EWSR1/EWS Recombinant Rabbit Monoclonal Antibody [JE49-57] (ET7109-94)
Synthetic peptide within n terminal human ewsr1/ews.
K562, A431, SK-BR-3, rat testis tissue, human thyroid gland tissue, human skin tissue, human breast cancer tissue, human pancreas tissue, mouse kidney tissue, mouse heart tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
68 kDa (Predicted band size)
bK984G1.4 antibody; bK984G1.4 Ewing sarcoma breakpoint region 1 protein antibody; Ewing sarcoma breakpoint region 1 antibody; Ewing sarcoma breakpoint region 1 protein antibody; Ewings sarcoma EWS Fli1 type 1 oncogene antibody; EWS antibody; EWS oncogene antibody; EWS RNA binding protein 1 antibody; EWS_HUMAN antibody; EWSR 1 antibody; Ewsr1 antibody; EWSR1 protein antibody; RNA binding protein EWS antibody; RNA-binding protein EWS antibody
Belongs to the RRM TET family.
Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266.; Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.
Cytoplasm. Plasma membrane. Nucleus.
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.