ENT1 Rabbit Polyclonal Antibody (ER1902-43)

UNIPROT #

Q99808

PROTEIN NAME

ENT1

SYNONYMS

Equilibrative NBMPR-sensitive nucleoside transporter antibody;equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter antibody;Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter antibody;Equilibrative nucleoside transporter 1 antibody;es-type antibody;MGC1465 antibody;MGC3778 antibody;Nucleoside transporter antibody;Nucleoside transporter, es-type antibody;OTTHUMP00000016506 antibody;OTTHUMP00000016507 antibody;OTTHUMP00000016508 antibody;OTTHUMP00000016509 antibody;OTTHUMP00000016510 antibody;OTTHUMP00000016511 antibody;OTTHUMP00000016512 antibody;S29A1_HUMAN antibody;Slc29a1 antibody;solute carrier family 29 (equilibrative nucleoside transporter), member 1 antibody;solute carrier family 29 (nucleoside transporters), member 1 antibody;Solute carrier family 29 member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.

TISSUE SPECIFICITY

Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Plasma membrane.

FUNCTION

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.