Estrogen Sulfotransferase Rabbit Polyclonal Antibody (HA500065)

UNIPROT #

P49888

PROTEIN NAME

Estrogen Sulfotransferase

SYNONYMS

EST antibody;EST-1 antibody;EST1 antibody;Estrogen sulfotransferase antibody;estrogen-preferring antibody;estrone sulfotransferase antibody;ST1E1 antibody;ST1E1_HUMAN antibody;STE antibody;Sulfotransferase 1E1 antibody;Sulfotransferase antibody;Sulfotransferase estrogen preferring antibody;Sulfotransferase family 1E member 1 antibody;SULT1E1 antibody

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Estrone sulfotransferase (EST) (EC 2.8.2.4), also known as estrogen sulfotransferase, is an enzyme that catalyzes the transformation of an unconjugated estrogen like estrone into a sulfated estrogen like estrone sulfate. It is a steroid sulfotransferase and belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. This enzyme participates in androgen and estrogen metabolism and sulfur metabolism. Steroid sulfatase is an enzyme that catalyzes the reverse reaction, the transfer of a sulfate to an unconjugated estrogen. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone . Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency . Does not sulfonate cortisol, testosterone and dopamine .