UNIPROT #

P11474

PROTEIN NAME

Estrogen Related Receptor alpha

SYNONYMS

Err 1 antibody; ERR a antibody; ERR alpha antibody; ERR-alpha antibody; Err1 antibody; ERR1 protein antibody; ERR1_HUMAN antibody; ERRa antibody; ERRalpha antibody; ESRL 1 antibody; ESRL1 antibody; ESRR A antibody; Esrra antibody; Estrogen receptor like 1 antibody; Estrogen receptor related 1 antibody; estrogen receptor related receptor alpha antibody; Estrogen receptor-like 1 antibody; Estrogen related receptor alpha antibody; Estrogen-related receptor alpha antibody; Estrra antibody; hERR1 antibody; NR3B1 antibody; Nuclear receptor subfamily 3 group B member 1 antibody; Steroid hormone receptor ERR1 antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR3 subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.; Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.; Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Estrogen related receptor alpha (ERRα) is a nuclear receptor in the superfamily of ligand-regulated transcription factors and is a member of the NR3B orphan nuclear receptor subgroup (consisting of α, β and γ). ERRα plays a role in modulating the estrogen signaling pathway. In addition, the expression of ERRα has been shown to increase during fasting and cold exposure. ERRα may be important for regulating mitochondrial biogenesis and oxidative metabolism by acting directly on genes necessary for mitochondrial function. Mice lacking ERRα are unable to maintain their body temperature in the cold. ERRα may also be involved in the maintenance and formation of cartilage. This information could be useful in finding therapeutic agents for a variety of diseases affecting the joints.