Rabbit polyclonal primary
ESD Rabbit Polyclonal Antibody (R1511-9)
K562, mouse intestine tissue lysate, Hela, LOVO, SW480, human prostate tissue, human pancreas tissue, mouse colon tissue.
Store at +4Cafter thawing. Aliquot store at -20Cor -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
EC 220.127.116.11 antibody; Es-10 antibody; Es10 antibody; ESD antibody; ESTD_HUMAN antibody; Esterase 10 antibody; Esterase D antibody; Esterase D formylglutathione hydrolase antibody; FGH antibody; FGH, included antibody; FLJ11763 antibody; Methylumbelliferyl acetate deacetylase antibody; MGC139609 antibody; OTTHUMP00000018374 antibody; OTTHUMP00000040929 antibody; S formylglutathione hydrolase antibody; S-formylglutathione hydrolase antibody; S-formylglutathione hydrolase, included antibody; Sid 478 antibody; sid478 antibody
Belongs to the esterase D family.
Cytoplasm. Cytoplasmic vesicle.
ESD (esterase D) is also known as S-formylglutathione hydrolase and is a 282 amino acid protein that is a member of the esterase D family. ESD is highly expressed in placenta, kidney, liver and erythrocytes, and is localized to the cytoplasm, as well as to cytoplasmic vesicles. The main function of ESD is to detoxify formaldehyde while providing energy. Formaldehyde is oxidized by ADH5 which yields S-formylglutathione. ESD then catalyzes the hydrolysis of S-formylglutathione to the reduced forms of formic acid and glutathione. In addition, ESD hydrolyzes a variety of different neutral ester substrates and can act as a carboxylesterase. ESD may also act as a cysteine hydrolase which is inactivated by thiol alkylating agents. ESD gene polymorphism can lead to reduced enzymatic activity which may cause susceptibility to many conditions, including toxic liver cirrhosis, retinoblastoma, obesity and autism.