ERK2 Recombinant Mouse Monoclonal Antibody [C3B12-R] (HA601201)

UNIPROT #

P28482

PROTEIN NAME

ERK2

SYNONYMS

ERK 2 antibody;ERK-2 antibody;ERT1 antibody;Extracellular Signal Regulated Kinase 2 antibody;Extracellular signal-regulated kinase 2 antibody;MAP kinase 1 antibody;MAP kinase 2 antibody;MAP kinase isoform p42 antibody;MAPK 1 antibody;MAPK 2 antibody;Mapk1 antibody;MAPK2 antibody;Mitogen-activated protein kinase 1 antibody;Mitogen-activated protein kinase 2 antibody;MK01_HUMAN antibody;P38 antibody;P40 antibody;P41 antibody;p42-MAPK antibody;P42MAPK antibody;PRKM1 antibody;PRKM2 antibody;protein kinase, mitogen-activated, 1 antibody;protein kinase, mitogen-activated, 2 antibody;protein tyrosine kinase ERK2 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, spindle, Nucleus, microtubule organizing center, centrosome, Membrane, caveola, Cell junction, focal adhesion.

FUNCTION

Mitogen-activated protein kinase (MAPK) signaling pathways involve two closely related MAP kinases, known as extracellular-signal-related kinase 1 (ERK 1, p44) and 2 (ERK 2, p42). Growth factors, steroid hormones, G protein-coupled receptor ligands, and neurotransmitters can initiate MAPK signaling pathways. Activation of ERK1 and ERK2 requires phosphorylation by upstream kinases such as MAP kinase kinase (MEK), MEK kinase and Raf-1. ERK1 and ERK2 phosphorylation can occur at specific tyrosine and threonine sites mapping within consensus motifs that include the Threonine-Glutamate-Tyrosine motif. ERK activation leads to dimerization with other ERKs and subsequent localization to the nucleus. Active ERK dimers phosphorylate serine and threonine residues on nuclear proteins and influence a host of responses that include proliferation, differentiation, transcription regulation and development. The human ERK2 gene maps to chromosome 22q11.21 and encodes a 360-amino acid protein.