ERK2 Recombinant Mouse Monoclonal Antibody [5-D2-R] (HA601202)

UNIPROT #

P28482

PROTEIN NAME

ERK2

SYNONYMS

ERK 2 antibody;ERK-2 antibody;ERT1 antibody;Extracellular Signal Regulated Kinase 2 antibody;Extracellular signal-regulated kinase 2 antibody;MAP kinase 1 antibody;MAP kinase 2 antibody;MAP kinase isoform p42 antibody;MAPK 1 antibody;MAPK 2 antibody;Mapk1 antibody;MAPK2 antibody;Mitogen-activated protein kinase 1 antibody;Mitogen-activated protein kinase 2 antibody;MK01_HUMAN antibody;P38 antibody;P40 antibody;P41 antibody;p42-MAPK antibody;P42MAPK antibody;PRKM1 antibody;PRKM2 antibody;protein kinase, mitogen-activated, 1 antibody;protein kinase, mitogen-activated, 2 antibody;protein tyrosine kinase ERK2 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, spindle, Nucleus, microtubule organizing center, centrosome, Membrane, caveola, Cell junction, focal adhesion.

FUNCTION

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.