ERK1 Rabbit Polyclonal Antibody (ER131011)

UNIPROT #

P27361

PROTEIN NAME

ERK1

SYNONYMS

ERK 1 antibody;ERK antibody;ERK-1 antibody;ERK1 antibody;ERT 2 antibody;ERT2 antibody;Extracellular Signal Regulated Kinase 1 antibody;Extracellular signal related kinase 1 antibody;Extracellular signal-regulated kinase 1 antibody;HGNC6877 antibody;HS44KDAP antibody;HUMKER1A antibody;Insulin Stimulated MAP2 Kinase antibody;Insulin-stimulated MAP2 kinase antibody;MAP kinase 1 antibody;MAP kinase 3 antibody;MAP Kinase antibody;MAP kinase isoform p44 antibody;MAPK 1 antibody;MAPK 3 antibody;MAPK antibody;MAPK1 antibody;Mapk3 antibody;MGC20180 antibody;Microtubule Associated Protein 2 Kinase antibody;Microtubule-associated protein 2 kinase antibody;Mitogen Activated Protein Kinase 3 antibody;Mitogen-activated protein kinase 1 antibody;Mitogen-activated protein kinase 3 antibody;MK03_HUMAN antibody;OTTHUMP00000174538 antibody;OTTHUMP00000174541 antibody;p44 ERK1 antibody;p44 MAPK antibody;p44-ERK1 antibody;p44-MAPK antibody;P44ERK1 antibody;P44MAPK antibody;PRKM 3 antibody;PRKM3 antibody;Protein Kinase Mitogen Activated 3 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Cell junction, Membrane.

FUNCTION

Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs, such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines , and research investigators consider it an important target in the diagnosis and treatment of cancer . Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family, as well as Mos and Tpl2/COT. MEK1 and MEK2 are the primary MAPKKs in this pathway.