ERG Rabbit Polyclonal Antibody (R1401-14)

UNIPROT #

P11308

PROTEIN NAME

ERG

SYNONYMS

Avian erythroblastosis virus E-26 (v-ets) oncogene related antibody;D030036I24Rik antibody;Erg 3 antibody;Erg antibody;ERG/EWS fusion gene, included antibody;ERG/FUS fusion gene, included antibody;ERG/TMPSSR2 fusion gene, included antibody;ERG_HUMAN antibody;ERG1, included antibody;ERG2, included antibody;ets related antibody;ETS-related gene antibody;KCNH2 antibody;Oncogene ERG antibody;p55 antibody;TMPRSS2/ERG fusion antibody;transcriptional regulator ERG (transforming protein ERG) antibody;Transcriptional regulator ERG antibody;Transforming protein ERG antibody;v ets avian erythroblastosis virus E26 oncogene antibody;v ets avian erythroblastosis virus E26 oncogene related antibody;v ets erythroblastosis virus E26 oncogene homolog antibody;v ets erythroblastosis virus E26 oncogene like antibody;v ets erythroblastosis virus E26 oncogene like isoform 2 antibody;v-ets erythroblastosis virus E26 oncogene antibody;v-ets erythroblastosis virus E26 oncogene homolog (avian) antibody;V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e antibody

SEQUENCE SIMILARITIES

Belongs to the ETS family.

SUBCELLULAR LOCATION

Nucleus, cytoplasm

FUNCTION

Transcriptional regulator ERG is a nuclear protein that binds purine-rich sequences of DNA. Transcriptional regulator ERG is required for platelet adhesion to the subendothelium and regulates hematopoiesis. It has a DNA binding domain and a PNT (pointed) domain. ERG is expressed at higher levels in early myelocytes than in mature lymphocytes (types of white blood cells). Therefore ERG may act as a regulator of differentiation of early hematopoietic cells. This gene can be classified as a proto-oncogene, which participates in chromosomal translocations (a popular example of this phenomenon is the Philadelphia chromosome). Essentially during cell division ERG can accidentally get stuck onto a different chromosome than where it belongs.