Recombinant Rabbit monoclonal primary
ERG Recombinant Rabbit Monoclonal Antibody [SP06-04] (ET1604-21)
Synthetic peptide within c-terminal of human erg.
Jurkat cell lysates, CRC, PC-3M, human colon carcinoma tissue, mouse brain tissue, mouse heart tissue, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Avian erythroblastosis virus E-26 (v-ets) oncogene related antibody; D030036I24Rik antibody; Erg 3 antibody; Erg antibody; ERG/EWS fusion gene, included antibody; ERG/FUS fusion gene, included antibody; ERG/TMPSSR2 fusion gene, included antibody; ERG_HUMAN antibody; ERG1, included antibody; ERG2, included antibody; ets related antibody; ETS-related gene antibody; KCNH2 antibody; Oncogene ERG antibody; p55 antibody; TMPRSS2/ERG fusion antibody; transcriptional regulator ERG (transforming protein ERG) antibody; Transcriptional regulator ERG antibody; Transforming protein ERG antibody; v ets avian erythroblastosis virus E26 oncogene antibody; v ets avian erythroblastosis virus E26 oncogene related antibody; v ets erythroblastosis virus E26 oncogene homolog antibody; v ets erythroblastosis virus E26 oncogene like antibody; v ets erythroblastosis virus E26 oncogene like isoform 2 antibody; v-ets erythroblastosis virus E26 oncogene antibody; v-ets erythroblastosis virus E26 oncogene homolog (avian) antibody; V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e antibody
Belongs to the ETS family.
ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. Transcriptional regulator ERG is required for platelet adhesion to the subendothelium and regulates hematopoiesis. It has a DNA binding domain and a PNT (pointed) domain. ERG is expressed at higher levels in early myelocytes than in mature lymphocytes (types of white blood cells). Therefore, ERG may act as a regulator of differentiation of early hematopoietic cells. Since ERG is important to the ability of the hematopoietic cells to function and self-renew, there may be applications in using blood stem cells for tissue repair, transplantation and other therapeutic applications. This gene can be classified as a proto-oncogene. During chromosomal translocations that occur in cell division, ERG can accidentally get stuck onto a different chromosome than where it belongs. This results in fusion gene products, which can have bad consequences for cells. Examples of these fusion gene products would be TMPRSS2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing’s sarcoma, and FUS-ERG in acute myeloid leukemia.